Long-term outcomes of isolated limb perfusion with hyperthermia in patients with soft tissue sarcomas

In case of locally advanced soft tissue sarcomas the extremities (STS), large size which does not allow resection with preservation limb, isolated regional perfusion (IRP) limb is considered as one effective treatment options. Aim. To evaluate long-term outcomes IRP melphalan under conditions hyperthermia for STS extremities. Materials and methods. We conducted a prospective cohort clinical study that included 42 patients All underwent melphalan, in – combination tumor necrosis factor alpha. Additional lymph node dissection was performed 8 cases (19%). The 5-year overall survival estimated by Kaplan-Meier method. Results. median age 50 years (from 24 to 80 years), women predominated 32 (76%). upper diagnosed 14 (33%), lower 28 (67%). G3 grade verified 34 (81%) patients, rest G2. Most had recurrent cases. received previous treatment: surgery chemotherapy / or radiation therapy 36 (86%), alone 2 (5%), 4 (9%) patients. Within 5 years, recurrence developed 20 (48%) amputation 10 (24%) distant metastases were (10%) mean time relapse after IPC 9.3 ± 3.5 months. Overall at 1, 2, 3, 4, 98%, 88%, 86%, 74%, 67%, respectively. Conclusion. an method extremities: rate 67% low amputations metastasis.